Site Accessibility Statement
Wilfrid Laurier University Faculty of Science
September 21, 2017
Canadian Excellence

Stephanie DeWitte-Orr


email: Stephanie DeWitte-Orr
phone: 519-884-0710
ext: 4317



1. Invited Reviews

DeWitte-Orr, S.J., and Mossman, K.L. (2010) Double-stranded RNA and the innate antiviral immune response. Future Virology. 5(3): 325-341.

2. Book Chapters

DeWitte-Orr S.J. and Mossman, K.L. (2011) Double-stranded RNA as a viral toxin (Chapter 1). In: Viruses and Interferon: Current Research. Mossman, K. (ed). Horizon Scientific Press, Chichester, UK, p. 1-19. 

Bols N.C., DeWitte-Orr S.J., Brubacher, J.L., Dixon B., and Ganassin R.C. (2003). Cell culture approaches in aquatic immunotoxicology (Chapter 16). In: In vitro methods in aquatic toxicology. Mothershill, C. and Austin, B. (eds). Springer Praxis, Chichester, UK, p. 399-413.

3. Research Articles Published

Poynter S.J., and DeWitte-Orr S. J.(2015) Length effects of dsRNA on type I IFN-mediated responses in the rainbow trout (Oncorhynchus mykiss )cell line, RTG-2. Fish and Shellfish Immunology. 46(2): 557-65.

Poynter S.J., Weleff, J., Soares, A.B., and DeWitte-Orr, S. J. (2015) Class-A scavenger receptor function and expression in the rainbow trout (Oncorhynchus mykiss) epithelial cell lines RTgutGC and RTgill-W1. Fish and Shellfish Immunology. 44(1): 138-46.

Poynter, S., Lisser, G., Monjo, A. and DeWitte-Orr, S. J. (2015) Viral nucleic acid PRRs in Fish. Biology. Biology 4(3): 460-93. For a special issue: Current Understanding of Fish Immune Systems.

Thatte, A., DeWitte-Orr, S.J., Mossman, K.L. and Ashkar, A. (2011) A critical role for interleukin-15 in TLR mediated protection against HSV-2. Journal of Immunology and Cell Biology. Ms no. ICB-10-00-0384V2. In press.

DeWitte-Orr, S.J., Collins, S.E., Bauer, C.M.T., Bowdish, D.M., and Mossman, K.L. (2010) An accessory to the ‘trinity’: SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses. PLoS Pathogens. Mar 26; 3(3):e1000829. Article featured as cover image for the March issue of journal.

Kawano, A., Kales, S.C., Fujiki, K., DeWitte-Orr, S.J., Dixon, B., Lee, L.E., and Bols, N.C. (2010). A comparison of rainbow trout cell lines for their expression of the major histocompatibility complex genes and the induction of beta-2-microglobulin by dsRNA. Fish and Shellfish Immunology. 29(2): 312-8.

DeWitte-Orr, S.J., Mehta, D.R., Collins, S.E., Suthar, M., Gale Jr., M., and Mossman, K.L. (2009) Long dsRNA induces an antiviral response independent of IRF3, IPS-1 and IFN. Journal of Immunology. 183(10):6545-53.

Bauer, C.M.T., DeWitte-Orr, S.J., Hornby, K.R., Zavitz, C.C.J., Lichty, B.D., Stampfli, M.R. and Mossman, K.L. (2008) Cigarette smoke suppresses type I interferon-mediated antiviral immunity in human lung fibroblast and epithelial cells. Journal of Interferon and Cytokine Research. 28(3):167-79.

Tafalla, C., Sanchez, E., Lorenzen, N., DeWitte-Orr, S.J. and Bols, N.C. (2008) Effects of viral hemorrhagic septicemia virus (VHSV) on the rainbow trout (Oncorhynchus mykiss) monocyte cell line RTS-11. Molecular Immunology. 45(5):1439-48.

DeWitte-Orr, S.J. and Bols, N.C. (2007) Cytopathic effect of chum salmon reovirus to salmonid epithelial, fibroblast and macrophage cell lines. Virus Research. 126(1-2) 157-71.

Peters, Z.J., Nykamp, J.A., Passaperuma, K., Carlson, J.C., DeWitte-Orr, S.J., Greenberg, B.M. and Bols, N.C. (2007) Effect of copper on the cytotoxicity of phenanthrene and the 9,10 phenanthrene quinone to the human placental cell line, JEG-3. Reproductive Toxicology. 23(4):513-20.

DeWitte-Orr, S.J., Leong, J.A. and Bols, N.C. (2007) Induction of antiviral genes, Mx and vig-1, by dsRNA and Chum salmon reovirus in rainbow trout monocyte/macrophage and fibroblast cell lines. Fish and Shellfish Immunology. 23(3): 670-82.

Kales, S.C., DeWitte-Orr, S.J., Bols, N.C., Dixon, B. (2007) Response of the rainbow trout monocyte/macrophage cell line, RTS11 to the water molds Achlya & Saprolegnia. Molecular Immunology. 44(9): 2303-2314.

DeWitte-Orr, S.J., Hsu, H.C.H. and Bols, N.C. (2007) Induction of homotypic aggregation in the rainbow trout macrophage-like cell line, RTS11. Fish and Shellfish Immunology. 22(5): 487-497.

DeWitte-Orr, S. J., Lepic, K., Bryson, S. P., Walsh, S. K., Lee, L. E. J. and Bols, N. C. (2006) Development of a continuous cell line, PBLE, from an American Eel peripheral blood leukocyte preparation. In Vitro Cellular and Developmental Biology-Animal. 42(8-9): 263-72.

Reinhart, B., DeWitte-Orr, S.J., Van Es, S.J., Bols, N.C., and Lee, L.E.J. (2006) Cell adhesion characteristics of a monocytic cell line derived from rainbow trout, Oncorhynchus mykiss. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology 144(4):437-443.

DeWitte-Orr, S.J., and Bols, N.C. (2005) Gliotoxin-induced cytotoxicity in three salmonid cell lines: cell death by apoptosis and necrosis. Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology 141(2):157-167.

Dayeh, V.R., Grominsky, S., DeWitte-Orr, S.J., Sotornik, D., Yeung, C.R., Lee, L.E.J., Lynn, D.H., Bols, N.C. (2005) Comparing a ciliate and a fish cell line for their sensitivity to several classes of toxicants by the novel application of multiwell filter plates to Tetrahymena. Research in Microbiology 156(1):93-103.

DeWitte-Orr, S.J., Zorzitto, J.R., Sutton, L.P., and Bols, N.C. (2005) Preferential induction of apoptosis in the rainbow trout macrophage cell line, RTS11, by actinomycin D, cycloheximide and double stranded RNA. Fish and Shellfish Immunology 18(4):279-295.

Brubacher, J.L., DeWitte-Orr, S.J., Zorzitto, J.R., and Bols, N.C. (2003). Redox-active metals in commercial preparations of lipopolysaccharide: implications for studies of cellular responses to bacterial products. Cellular Microbiology5(4):233-43.