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December 3, 2016
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Paul Mallet

7-OH-DPAT produces place conditioning in rats

European Journal of Pharmacology, 261, R5-R6.
Mallet, P.E. & Beninger, R.J.

published: 1994 | Research publication | Journal article

Abstract: The rewarding properties of the putative dopamine D3 receptor-selective agonist, 7-OH-DPAT ((+/-)-2-dipropylamino-7-hydroxy-1,2,3,4- tetrahydronaphthalene hydrobromide), were investigated using a place conditioning paradigm consisting of three phases: preconditioning (three undrugged exposures to an apparatus consisting of two visually distinct compartments); conditioning (four pairings of one compartment with drug); and test (one undrugged exposure to the same apparatus). Rats received either saline, amphetamine (2.0 mg/kg), or 7-OH-DPAT (0.5, 2.0 or 5.0 mg/kg) during conditioning. Amphetamine and 7-OH-DPAT produced a place preference.

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